Editorial expression of concern: Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules.

BIOCHEMISTRY PNAS is publishing an Editorial Expression of Concern regarding the following article: “Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules,” by Qidong Hu, Young-Soo Kwon, Esperanza Nunez, Maria Dafne Cardamone, Kasey R. Hutt, Kenneth A. Ohgi, Ivan Garcia-Bassets, David W. Rose, Christopher K.Glass,Michael G. Rosenfeld, andXiang-Dong Fu, which appeared in issue 49, December 9, 2008, of Proc Natl Acad Sci USA (105:19199–19204; first published December 3, 2008; 10.1073/pnas.0810634105). The editors note that in January 2014, upon the authors’ request, PNAS published a correction to three figures in this article. Subsequent to the publication of the correction, the editors received concerns regarding images appearing in two of the corrected figures (Fig. 2B and Fig. S2) when compared with the data in the retracted Cell paper (1). In this regard, the authors note that the images in both the corrected Fig. 2B and Fig. S2 correspond to specific cells saved from large, multi-nuclei–containing photographic images. The authors note that this image-to-cell correspondence indicates that the incorrect cells shown in the retracted Cell paper resulted from errors in image processing. However, the original microscopy data is no longer available to further verify the accuracy of the images in question. Inder M. Verma Editor-in-Chief